Prey tells the story of Tommy, a Cherokee garage mechanic stuck on a reservation going nowhere. Abducted along with his people to a menacing mothership orbiting Earth, he sets out to save himself and his girlfriend and eventually his planet.

In Prey, players enter a living spaceship which enslaves alien races and devours humans for lunch. A unique twist on the first person shooter genre, Prey features such innovations as the ability to walk on walls, manipulate gravity and perform a "spirit walk" by leaving your physical body behind. Designed by Human Head (under the direction of 3D Realms), Prey features full online support for up to eight players, utilizing the game's play innovations for unique multiplayer experiences.